孙长凯-轻识

人物介绍

孙长凯

现为大连医科大学中青年学科带头人，神经病学主任医师、教授，脑疾病研究所所长，辽宁省脑疾病重点实验室暨辽宁省高校省级脑疾病研究重点实验室主任，博士生导师，博士后合作导师，大连医科大学科技处处长。主要从事癫痫等重大脑疾病防治研究。建立解放军大连210医院神经心理学诊疗室、大连医科大学脑疾病研究所、辽宁省高校省级脑疾病研究重点实验室及辽宁省脑疾病重点实验室。承担各类基金课题30余项。

1992年开始兴奋毒性脑损害中的活性氮介质机制研究，提出“一氧化氮-星形胶质细胞抗兴奋毒性脑损害”新的级联机制，揭示了L-精氨酸/一氧化氮介质抗兴奋毒性的脑保护作用。1997年提出“癫痫及其相关、相似脑疾病免疫防治的创新性研究”构想，提出“神经疫苗”概念及其第一个“神经疫苗”研究课题。2000年开始研制银杏叶提取物纳米制剂并应用于兴奋毒性脑损害的防治。

2003年4月提出“SARS胆碱能急救疗法”，受到卫生部专家组肯定。发表论文百余篇，部分内容被收入1996年Portland出版社出版的Biology of Nitric Oxide丛书（第5辑）、2008年Lippincott Williams & Wilkins (LWW)出版社出版的美国新版《癫痫学》教材（Epilepsy: A Comprehensive Textbook, 2nd Edition. Jerome Engel Jr., Timothy A. Pedley与Jean Aicardi主编。此书是当代国际上最大、最有影响的三卷本《癫痫学》教材与工具书，第二版全书共3056页）。应邀在第22届世界癫痫大会上做15分钟口头报告（1997，都柏林），参与组织和主持了全国第一次一氧化氮生物医学研究与应用学术会议（1997年），参编（责任编委/编委）著作/教材8部（包括中国科技大学研究生教材及全国研究生规划教材）。获辽宁省科技进步一等奖一项，辽宁省科技进步二等奖两项，军队科技进步二、三、四等奖各一项，武装警察部队科技进步二等奖一项。

2001年提出开设硕/博士研究生及七/八年制学生新课程《“临床神经生物学”》，获辽宁省第五届高等教育教学成果三等奖，2005年国家级继续教育项目12学分。

中华神经科杂志

2002年提出“科技工作和科技管理工作的6P目标与指标”。主要学术与社会兼职：中国生理学会应用生理专业委员会副主任委员，中国神经科学学会理事，中国机械工程学会生物制造工程分会第一届专业委员会委员暨高级会员，中德（教育部高等教育出版社-Springer）Frontiers of Medicine in China第一、二届编委，中华医学会神经病学专业委员会会刊《中华神经科杂志》第三、四届编委，Neuroscience（国际脑研究组织IBRO官方期刊），Chin Med J（《中华医学杂志英文版》），Prog Biochem Biophys（《生物化学与生物物理进展》）等SCI期刊审稿专家，科技部生物技术发展中心国家863计划生物与医药领域评审专家，教育部科技发展中心中国科技论文在线优秀学者，中华医学科技奖第二届评审委员会委员。辽宁省神经科学学会理事长，辽宁省医药质量管理学会副会长，辽宁省药学会第八届生化与生物技术药物专业委员会副主任委员，辽宁省医学会医学科研管理分会副主任委员，辽宁省生物技术协会第三届理事会常务理事兼副秘书长，中华医学会辽宁省医学会第五届理事会常务理事，辽宁省生理学会第六届理事会常务理事，辽宁省首届医师协会常务理事，辽宁省经济体制改革研究会理事会常务理事。中华医学会大连市分会第八届理事会理事，生理学专科分会主任委员，大连市社会科学院特邀研究员，大连医科大学大连市社会科学院研究基地医学社会科学研究中心主任兼生物医学科研管理研究室主任。美国科学促进协会（AAAS）会员，纽约科学院（NYAS）Active Member。

工作履历

2000年10月至2016年9月，任大连医科大学主任医师、教授。

2016年9月至今，任大连理工大学电信学部生物医学工程系教授。

荣誉记录

2020年5月，获得第二届全国创新争先奖。

代表性论文

1. Cao J, Sun CK (Corresponding Author), Zhao H, Xiao Z, Chen B, Gao J, Zheng T, Wu W, Wu S, Wang J, Dai J(Corresponding Author). The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats. Biomaterials.2011 Jun;32(16):3939-48 (通讯作者，2009SCI影响因子IF7.365)

2. Kisiel-Sajewicz K, Fang Y, Hrovat K, Yue GH, Siemionow V, Sun CK, Jaskólska A, Jaskólski A, Sahgal V, Daly JJ. Weakening of synergist muscle coupling during reaching movement in stroke patients. Neurorehabil Neural Repair. 2011 May;25(4):359-68(2009SCI影响因子IF 5.398)

3. Hao M, Li SY, Sun CK, Jingyu-Xu, Lin Y, Liu KX, Wang L, Li CX, Zhou Q, Du JL, Li H. Amelioration effects of berberine on diabetic microendothelial injury model by the combination of high glucose and advanced glycation end products in vitro. Eur J Pharmacol. 2011 Mar 11;654(3):320-5(2009SCI影响因子IF2.585)

4. Li S, Luo J, Wang X, Guan BC，Sun CK(Corresponding Author). Effects of Ginkgo biloba extracts on NMDA-activated currents in acutely isolated hippocampal neurons of the rat. Phytother Res. 2011 Jan;25(1):137-41 (通讯作者，2009SCI影响因子IF1.746)

5. Li A, Lv S, Yu Z, Zhang Y, Ma H, Zhao H, Piao H, Li S, Zhang N, Sun CK. Simvastatin attenuates hypomyelination induced by hypoxia-ischemia in neonatal rats. Neurol Res. 2010 Nov;32(9):945-52(2009SCI影响因子IF 1.277)

6. Ma XC,Sun CK (Corresponding Author), Huang SS, Wang JK, Zhang BJ, Li FY, Wang G, Deng S, Cui J(Corresponding Author). Preparative isolation and purification of four prenylflavanones from microbial biotransformation of kurarinone by high-speed counter-current chromatography. Sep Purif Technol. 2010;76:140-5 (通讯作者，2009SCI影响因子IF 2.879)

7. Song Z, He CD, Sun CK, Xu Y, Jin X, Zhang Y, Xiao T, Wang Y, Lu P, Jiang Y, Wei H, Chen HD. Increased expression of MAP2 inhibits melanoma cell proliferation, invasion and tumor growth in vitro and in vivo.Exp Dermatol. 2010 Nov;19(11):958-64(2008SCI影响因子IF3.295)

8.Yin LH, Xu YW, Qi Y, Han X, Xu LN, Peng JY(Corresponding Author), Sun CK(Corresponding Author). A green and efficient protocol for industrial-scale preparation of dioscin from Dioscorea nipponica Makino by two-step macroporous resin column Chromatography. Chem Eng J 2010,165:281-289 (通讯作者，2009SCI影响因子IF 2.816)

9. Li J, Ma X, Li F, Wang J, Chen H, Wang G, Lv X, Sun CK(Corresponding Author), Jia J. Preparative separation and purification of bufadienolides from Chinese traditional medicine of ChanSu using high-speed counter-current chromatography. J Sep Sci 2010,33:1325-1330 (通讯作者，2009SCI影响因子IF 2.551)

10. Yu Z, Li S, Lv SH, Piao H, Zhang YH, Zhang YM, Ma H, Zhang J, Sun CK, Li AP(Corresponding Author). Hypoxia-ischemia brain damage disrupts brain cholesterol homeostasis in neonatal rats. Neuropediatrics 2009,40(4):179-185 (SCI影响因子IF1.377)

11.Wu JL, Liu T, Lin Y, Shen ZW, Miao YW, Wu RH, Sun CK. Quantitative analysis of glutamate compounds in the swine brain following central analgesics nasal spray using proton magnetic resonance spectroscopy and linear combination model. Neural Regen Res 2009,4(7): 508-512 (SCI检索期刊)

12.Du JL, Liu JF, Men LL, Yao JJ, Sun LP, Sun GH, Song GR, Yang Y, Bai R, Xing Q, Li CC, Sun CK (Corresponding Author). Efffects of five-year intensive multifactorial intervention on the serum amyloid A and macroangiopathy in patients with short-duration type 2 diabetes mellitus. Chin Med J 2009, 122(21): 2560-2566 (通讯作者，SCI影响因子IF 0.952)

13.Sun W, Sun CK, Lin H, Zhao H, Wang J, Ma H, Chen B, Xiao Z, Dai J. The effect of collagen-binding NGF-beta on the promotion of sciatic nerve regeneration in a rat sciatic nerve crush injury model. Biomaterials 2009 Sep;30(27):4649-56. (中国科学院遗传与发育研究所来本实验室完成的联合研究，SCI影响因子IF7.365)

14.Sun W, Sun CK, Zhao H, Lin H, Han Q, Wang J, Ma H, Chen B, Xiao Z, Dai J. Improvement of sciatic nerve regeneration using laminin-binding human NGF-beta. PLoS One 2009 Jul 9;4(7):e6180 (中国科学院遗传与发育研究所来本实验室完成的联合研究，SCI影响因子IF4.351)

15.Chen X, Sun CK (Co-First Author), Han GZ, Peng JY, Li Y, Liu YX, Lv YY, Liu KX, Zhou Q, Sun HJ. Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significanly correlated with cytochrome P450 suppression. World J Gastroenterol 2009 Apr 21;15(15):1829-35(并列第一作者，SCI影响因子IF2.092)

16.Yin LH, Lu BN, Qi Y, Xu LN, Xu H, Xu YW, Peng JY(Corresponding Author), Sun CK (Corresponding Author). Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control.J Pharm Biomed Anal 2009 May 1;49(4):1101-8 (通讯作者，SCI影响因子IF 2.453)

17.Wang XF, Yang Q, Fan Z, Sun CK, Yue GH. Assessing time-dependent association between scalp EEG and muscle activation: a functional random-elects model approach. J Neurosci Methods 2009 Feb 15;177(1):232-40 (SCI影响因子IF2.295)

18.XuLN, Han X, Qi Y, Xu YW, Yin LH, Peng JY(Corresponding Author), Liu KX, Sun CK (Corresponding Author). Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Anal Chim Acta 2009 Feb 2;633(1):136-48 (通讯作者，SCI影响因子IF3.757)

19.Yang Q, Fang Y, Sun CK, Siemionow V, Ranganathan VK, Khoshknabi DS, Davis MP, Wash D, Sahgal V, Yue GH. Weakening of corticomuscular coupling during muscle fatigue. Brain Res, 2009 Jan 23; 1250: 101-112(SCI影响因子IF2.463)

20.Liang S, Yang F, Zhou C, Wang Y, Li S, Sun CK, Puglisi JL, Bers D, Sun C, Zheng J. Temperature-dependent activation of neurons by continuous near-infrared laser.Cell Biochem Biophys2009;53(1):33-42(SCI影响因子IF3.337)

21.Zhan LB, Sui H, Lu XG, Sun CK, Zhang J, Ma H.Effects of Zibu Piyin Recipe on SNK-SPAR pathway in neuron injury induced by glutamate. Chin J Integr Med 2008 ,14(2):117-122 (SCI检索期刊)

22.Liu S, Sun MZ, Sun CK, Zhao B, Greenaway FT, Zheng Q. A novel serine protease from the snake venom of Agkistrodon blomhoffii ussurensis.Toxicon. 2008; 52(7): 760-8 (SCI影响因子IF 2.460)

23.Zhang L, Butler AJ, Sun CK, Sahgal V, Wittenberg GF, Yue GH. Fractal dimension assessment of brain white matter structural complexity post stroke in relation to upper-extremity motor function. Brain Res 2008; 1228: 229-240 (SCI影响因子IF 2.494)

24.DU JL,Sun CK (Co-First Author), LÜ B, MEN LL, YAO JJ, AN LJ, SONG GR. Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus. Chin Med J 2008; 121(13): 1165-1168(并列第一作者，SCI影响因子IF 0.858)

25.Wu LX, Sun CK (Corresponding Author)，Zhang YM, Fan M, Xu J, Ma H, Zhang J. Involvement of the Snk-SPAR pathway in glutamate-induced excitotoxicity in cultured hippocampal neurons. Brain Res2007;1168:38-45 (通讯作者，SCI影响因子IF 2.218)

26.Du JL, An LJ, Sun CK, Men LL, Zhang XJ, Li CC. Overexpressing SelS may protect human umbilical vein endothelial cells from injuring by H2O2. Prog Biochem Biophys 2007, 34(4): 425-430(SCI影响因子IF 0.214)

27.Zhan LB, Lu XG, Sun CK, Wang DP, Sui H, Jiang WZ, Wei W, Ma H. Antiexcitoxicity of Zi-Bu-Pi-Yin Recipe in vitro and Mechanisms. Acta Pharmacol Sin 2006; 27 (Suppl): 352 (XVth World Congress of Pharmoclogy, Beijing, ISTP收录，SCI影响因子IF 1.397)

28. Kang XN, Sun CK (Corresponding Author), Fan M, Xue YN, Shao NS, Zhao J, Han DY, Shi GX. Screening of a NMDA receptor epitope from random phage display peptide library. Prog Biochem Biophys 2003, 30 (4): 599-604 (通讯作者，SCI影响因子IF 0.048)

29. Kang XN, Sun CK (Corresponding Author), Fan M, Song ZJ, Zhao J, Wang JQ, Shi GX. Fourier transform infrared spectroscopic investigation of excitotoxicity-protective mechanism of monoclonal antibody against NMDAR. Prog Biochem Biophys 2003, 30 (2): 290-294(通讯作者，SCI影响因子IF 0.048)

30. Wu LX,Sun CK (Corresponding Author), Fan M . Nogo and Nogo receptor . Prog Biochem Biophys 2002, 29 (6): 834-836(通讯作者，SCI影响因子IF 0.160)

31. Sun CK, Ju G. Nitric oxide involved in epilepsy: Yes or no, what or why. Jpn J Pharmacol 1997,75(Suppl.1):89 (第五届一氧化氮国际会议交流, ISTP收录，SCI影响因子IF 1.210)

32. Sun CK, Ju G, Huang YG. Expression of interleukin-6 in rat hippocampal formation during kainic acid induced seizures and the roles of nitric oxide pathway. Epilepsia1997,38 (Suppl.3): 231(第22届国际癫痫会议口头报告, ISTP收录，SCI影响因子IF 2.928)

33. Sun CK, Ju G, Huang YG. Implications of nitric oxide pathway in reactive gliosis within intractable seizure brain.Epilepsia1997,38(Suppl.3):189(第22届国际癫痫会议交流，SCI影响因子IF 2.928)

34. Chen JW,Sun CK, Huang YG. Nitric Oxide Synthase: Biochemistry and Molecular Biology. Prog Biochem Biophys 1996, 23 (3): 293-297(SCI影响因子IF 0.041)

35. Sun CK, Chong XQ, Huang YG. Spongiform encephalopathies in Chinese mainland. Lancet 1996, 348:544 (Research Letter)(SCI影响因子IF 17.948)

36. Sun CK, Huang YG, Wang DN,et al. An investigation of the GluRs-NOSs-RNI/ROIs cascade mechanism during the seizures induced by kainic acid in balb/c mice. Endothelium 1995,3:s119(Abstract)(第四届一氧化氮国际会议交流, ISTP收录，SCI影响因子1.146)